How cells regulate the dynamics of chromatin patterns
Cellular identity is closely interwoven with complex patterns of DNA and histone modifications, which partition our chromosomes and determine how cells interpret the genetic information. For cells to remember who they are, these patterns have to be tightly regulated over time and through cell division. In particular, chromatin patterns have to be restored after they have been remodeled in response to external signals, DNA replication or DNA damage. It is a key question how cells balance the plasticity and stability of these patterns.
In my talk, I will present simulations, live-cell and single-molecule experiments that I have conducted to assess how cells establish and maintain chromatin state patterns and the nuclear subcompartments they are associated with. I will put a focus on H3K9 trimethylation, which is a prominent histone mark involved in silencing heterochromatin.
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Dr Nicolas Le Novère
The Cambridge Building - Kings Hedges Room