Lysophospholipid Receptors: Discovery, Signaling & Therapeutics
Understanding the brain – how it develops, carries out complex tasks, and is affected by diseases – is the overall goal of our research. This is being pursued through two scientific areas that have both basic science and therapeutic implications: 1) lysophospholipid (LP) receptor signaling, involving small lipids that act as extracellular chemical signals; and 2) genomic mosaicism amongst single brain cells – especially neurons – whereby cells from the same individual can vary at the genomic level. Within these areas, we have placed a particular emphasis on translating the basic science research into an understanding and potential treatment of brain diseases, with current efforts aimed at hydrocephalus, Multiple Sclerosis (MS), Alzheimer’s Disease, and other neurodegenerative diseases.
*Introduction from the Chun Laboratory website*
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