Molecular mechanisms underlying cellular sensing and response to nutrients

mTOR and autophagy are two interconnected pathways mediating cellular nutrient sensing and adaptation. Both processes are essential for cellular health and their perturbation has been implicated in ageing and age-related diseases. The talk will illustrate our recent attempts to elucidate the mechanisms controlling mTOR and autophagy as well as to understand how these processes contribute to the maintenance of cellular physiology. The identified by us molecular mechanisms will be discussed in light of their relevance to human age-related pathology.