Epigenetic fixation of T cell fates
Although it is widely accepted that epigenetic mechanisms contribute to fixation of immune cell fates, molecular details are largely unknown. A better understanding of the events leading to engraved gene expression profiles will enable us to generate tailored immune cell subsets with epigenetically fixed functional properties for therapeutic purposes.
In my talk I will mainly focus on Foxp3+ regulatory T cells and Th17 cells and will discuss how epigenetic mechanisms contribute to their development and functional properties.
Dr Michelle Linterman
The Brian Heap Seminar Room