Regulation of X-chromosome inactivation in human development

Regulation of X-chromosome inactivation in human development

Sex-chromosome dosage compensation is essential in most metazoan, yet the developmental timing and the underlying strategies are remarkably variable, even amongst placental mammals. In the latter, dosage compensation is achieved through the inactivation of one X chromosome in females, a process that has been so far mostly studied in the mouse, where actors and mechanisms have been characterized. Here we will discuss new insights into how the activity of the X chromosome is regulated in human early development, and how long noncoding RNAs are contributing to this process.

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