Epigenetics, stem cells and emerging technologies
Epigenetic mechanisms lie at the heart of developmental decisions: they help lock in differentiated states and mediate gene activity changes in response to environmental change. Perhaps nowhere are epigenetic mechanisms more important than in governing the properties and potential of stem cells. This exciting mini-symposium, suitable for academic and commercial research scientists, will discuss epigenetic processes involved in regulating stem cells. We shall see that epigenetic modifications can extend beyond the realm of DNA and chromatin and look at some of the latest approaches that support epigenetic reprogramming and the derivation of induced pluripotent stem cells (iPSCs) in the quest to better understand human disease.
13:30 – 14:00 Arrival and Registration
14:00 – 14:30 David Sassoon, Stem Cells and Regenerative Medicine, Université de Pierre et Marie Curie-Sorbonne Universités, Paris
The imprinted gene PW1/Peg3 in adult stem cells - interplay between cell stress and regenerative responses.
14:30 – 15:00 Jose Silva, Wellcome Trust-MRC Stem Cell Institute & Department of Biochemistry
Reprogramming mechanisms of Oct4 and Nanog.
15:00 – 15:30 Ludovic Vallier, Wellcome Trust-Medical Research Council Stem Cell Institute & Wellcome Trust Sanger Institute
Activin/Nodal signalling controls the epigenetic status of human pluripotent stem cells
15:30 – 16:00 Coffee break
16:00 – 16:30 John Marioni, European Bioinformatics Institute
Applying spatially-referenced single-cell transcriptomics to non-model systems
16:30 – 17:00 Michaela Frye, Wellcome Trust-MRC Stem Cell Institute
Detection of the epitranscriptome
17:00– 17:30 Myriam Hemberger, Epigenetics Programme, Babraham Institute
Transcriptional networks in trophoblast stem cells
17:30 – 19:00 Drinks Reception
This FREE event is suitable for academic and commercial scientists, but registration is essential: http://bit.ly/1qEEgs0
Dr Tacita Nye
Conference Centre, Babraham Institute