Genomic approaches to study chromosome architecture and function
Bas gained his PhD in 1995 from the University of Amsterdam. He had postdoc positions at the Rockefeller University (Titia de Lange lab) and the Fred Hutchinson Cancer Research Center (Steve Henikoff lab), studying various aspects of chromosome biology. Since 2002 he is Research Group Leader at the NKI. He is EMBO Member; recipient of an EURYI award, VICI and ERC Advanced grants; he is Extraordinary Professor at Erasmus University Medical Centre, Rotterdam.
Chromatin is probably the most complex molecular ensemble in the cell. It consists of genomic DNA bound by hundreds of protein and RNA molecules. All of these components work in concert, and cannot be fully understood unless they are studied in their complete context. In addition, the spatial organization of interphase chromosomes is thought to be of key importance for genome expression and maintenance. Yet, this three-dimensional chromosome organization and its impact on gene regulation and other functions are still poorly understood.
In order to gain insight into these fundamental processes, we take a broad integrative genomics approach, using both fruit fly and mammalian cells as model systems. We conduct our studies in the living cell, in the context of the entire genome. We develop and apply new genomics techniques to reveal the interplay among many chromatin proteins, to visualize the architecture of chromosomes inside the nucleus, and to detect the genome-wide effects of these factors on gene expression. We analyze the large datasets that we generate using a range of bioinformatics approaches.
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