Generic patterns of clone dynamics in growing tissues
The development of an organism relies on the tightly orchestrated behaviour of many cells. How do these cells regulate their fate in order to build complex structures, like the heart or the brain? Underlying cell fate regulation are complex molecular programs and, and, with recent technological developments, we are now in a position to describe these molecular processes with increasing detail. But understanding how cellular states and behaviour emerge from these processes remains conceptually challenging. Given these challenges, can we infer mechanisms of cell fate regulation from tissue level measurements? In this talk I will discuss how methods from theoretical physics can help bridging these scales. Giving the example of lineage tracing in organ development will show that through the interplay of many cells generic patterns of clonal dynamics emerge, and how these patterns provide a quantitative basis for deciphering cell fate specific information.
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Professor Wolf Reik
The Brian Heap Seminar Room