siRNA-mediated assembly of heterochromatin – a kiss to remember
Marc Bühler is a Senior Group Leader and SNF Professor at the Friedrich Miescher Institute for Biomedical Research in Basel, Switzerland. His research focuses on the convergence of two seemingly disparate fields of study: chromatin biology and RNA turnover. Dr. Bühler’s research has provided fundamental mechanistic insights into how non-coding RNAs are used to control gene expression at the level of chromatin. In his Seminar he will talk about recent work from his laboratory that uncovers a novel mechanism for small-RNA-mediated epigenome regulation. In brief, although endogenous small RNAs play critical roles in chromatin-mediated processes across kingdoms, efforts to initiate chromatin modifications in trans by using siRNAs have been inherently difficult to achieve in all eukaryotic cells. Using fission yeast, Dr. Bühler’s group has discovered a counter-acting mechanism that impedes small RNA-directed formation of heterochromatin and epigenetic gene silencing. Their new work solves a long-standing problem in the field and highlights fundamental roles for the transcription and RNAi machineries in building epigenetic memory.
EU Life and the Babraham Institute
EU-LIFE is an alliance of European life science research centers that have joined forces to support, collaborate and strengthen scientific research in Europe, working together to achieve advancement and further understanding in Life Sciences.
The growing consortium currently consists of 13 partner Institutes and over 7,000 scientific staff with the Babraham Institute, currently the only UK representative, joining in 2013.
As part of the collaboration, the Babraham Institute are now proud to host a series of lectures to highlight and support the latest research from fellow members.
Dr Jon Houseley
The Brian Heap Seminar Room