EU Life Lecture - Temporal scaling of C. elegans Ageing
Ageing produces a wide distribution of lifespan even among isogenic individuals housed in controlled environments. Using our automated imaging platform, we found that many lifespan-extending interventions produce a similar effect on the C. elegans lifespan distribution--a temporal scaling. Interventions that produce this apparent stretching in respect to time include changes in diet and temperature, exposure to oxidative stress, and the disruption of genes including the insulin/IGF receptor, HSF-1, and DAF-16/FOXO.
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