Delineation of a common pathway to autoimmunity in humans?
I believe human and all placental mammal susceptibility to autoimmunity is a consequence of the evolution of an immune system to combat infections that threatened their existence, and of course as a happy side effect enabled successful reproduction. The evidence for this is written in comparative genomic data of mammals, but also in the much more recent history of genomic evolution in humans recorded by genome wide genetic variant associations of disease. Of course the odd mouse experiment helps to confirm that these suspicions are not a complete hallucination.
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