Antisense-mediated chromatin silencing
Caroline Dean did her PhD at the University of York, and then spent 5 years as a post-doctoral research fellow in a small biotech company in California. She started her lab at The John Innes Centre in Norwich in 1988, and served as Associate Research Director between 1999-2008. She is now a Royal Society Research Professor based at John Innes Centre. Her group’s work on why and how plants overwinter before flowering has led them into the study of antisense RNA and Polycomb switching mechanisms. Working with collaborators at MRC, LMB the group is currently studying the structural changes underpinning epigenetic switching mechanisms and R-loop mediated chromatin silencing.
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