Life Sciences Research for Lifelong Health

All kinds of JNK: How one kinase can be an oncogene, tumour suppressor and apoptotic mediator


The c-Jun N-terminal Kinase (JNK) was originally identified as a mediator of stress induced apoptosis, although it is now known to also play contradictory roles as both a key tumour suppressor and potent oncogene. Because of this pleotropic functionality, targeting JNK directly is unlikely to ever yield successful translation to the clinic. However, we now show that these distinct functions of JNK emerge from two subcellular-specific JNK signalling network states that can exist simultaneously within breast cancer cells, with opposing functional and prognostic roles. By utilising a novel protein-protein interaction based proteomics technique, and high content imaging with a JNK biosensor, we have specifically dissected the signalling complexes that regulate the subcellular activation of JNK in breast cancer. Through this analysis, we now demonstrate that targeting the subcellular activity of JNK represents a viable strategy for specifically inhibiting the oncogenic function of JNK, without impairing its key role as a tumour suppressor.

If you would like to attend this seminar, please contact us to arrange site access.

Event Time & Dates

Starts12:00 pm - 01/08/2019
Ends01:00 pm - 01/08/2019

Event Details

Contact Matt Humphries
LocationThe Cambridge Building - Kings Hedges Room
SpeakerDr David Croucher
Speaker AffiliationGroup Leader - Network Biology, Garvan Institute of Medical Research, Australia

Posted

8 July, 2019