Dynamics of Epigenetic Regulators for Chromatin Replication

​Chromatin structures, such as pericentromeric and centromeric heterochromatin are highly complex superstructures, characterized by specific histone modifications and non-histone proteins, for example, heterochromatin Protein 1 (HP1).

HeterochromatinThese assemblies are fully disrupted during and reassembled after replication. How such chromatin organizations are propagated during cell division is largely an enigma.

However, the faithful re-establishment of such chromatin domains is critical for viability. For example, loss of pericentromeric heterochromatin leads to defects in chromosome segregation and genomic instability. The machinery that is involved in chromatin replication is poorly characterized, most what is known centers on histone chaperones.

Our work highlights the critical role of chromatin remodeling factors in this process. Recently we implicated a so far poorly characterized chromatin remodeling factor called SMARCAD1 in the propagation of pericentromeric heterochromatin during replication.