Jenny Pell

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Signalling & Cell Fate - Regulation of adult muscle stem cell behaviour

Even though adult stem cells have restricted potency, they are nevertheless essential for successful postnatal life. We utilise the muscle satellite cell, a form of adult stem cell, as a model for the study of stem cell behavior.

These cells must respond to extrinsic signals to provide progeny that only only differentiates into specialised tissue (i.e. muscle) but must also self-renew.

Further muscle is a major metabolic tissue in the animal and its activity can have important consequences for adult-onset diseases such as type 2 diabetes.

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