Marianne Brüggemann
Tel. (01223) 496304

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• Recent, selected Publications

Marianne Brüggemann has joined BBT Ltd on secondment to pursue translational development of new technologies for monoclonal antibody production

The discovery that diverse heavy-chain-only antibodies can be expressed in the mouse has identified a new type of antigen recognition (J Exp Med 204: 3271-3283, 2007). Patents secure the findings and the aim of the technology is to produce novel therapeutic reagents which readily interact with moieties not recognised by conventional antibodies.

Recent, selected publications

Corcos D, Osborn MJ, Matheson LS, Santos F, Zou X, Smith JA, Morgan G, Hutchings A, Hamon M, Oxley D, Bruggemann M (2010) Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain.
Blood 115 282-288
http://dx.doi.org/10.1182/blood-2009-07-234864

Matheson LS, Osborn MJ, Smith JA, Corcos D, Hamon M, Chaouaf R, Coadwell WJ, Morgan G, Oxley D, Bruggemann M (2009) Light chain-deficient mice produce novel multimeric heavy-chain-only IgA by faulty class switching.
International Immunology 21 957-966
http://dx.doi.org/10.1093/intimm/dxp062

Zou X, Smith JA, Corcos D, Matheson LS, Osborn MJ, Bruggemann M (2008) Removal of the BiP-retention domain in Cμ permits surface deposition and developmental progression without L-chain.
Molecular Immunology 45 3573-3579
http://dx.doi.org/10.1016/j.molimm.2008.05.003

Zou X, Osborn MJ, Bolland DJ, Smith JA, Corcos D, Hamon M, Oxley D, Hutchings A, Morgan G, Santos F, Kilshaw PJ, Taussig MJ, Corcoran AE, Bruggemann M (2007) Heavy chain-only antibodies are spontaneously produced in light chain-deficient mice.
Journal of Experimental Medicine 204 3271-3283
http://dx.doi.org/10.1084/jem.20071155

Bruggemann M, Smith JA, Osborn MJ, Corcos D, Zou X, Nguyen VK, Muyldermans S (2006) Heavy-chain-only antibody expression and B-cell development in the mouse.
Critical Reviews in Immunology 26 377-390
http://www.edata-center.com/journals/2ff21abf44b19838,023606d26a204d18,01376f024c3514fe.html

Zou X, Smith JA, Nguyen VK, Ren L, Luyten K, Muyldermans S, Bruggemann M (2005) Expression of a dromedary heavy chain-only antibody and B cell development in the mouse.
Journal of Immunology 175 3769-3779
http://www.jimmunol.org/cgi/content/abstract/175/6/3769

Ren L, Zou X, Smith JA, Bruggemann M (2004) Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region.
Genomics 84 686-695
http://dx.doi.org/10.1016/j.ygeno.2004.06.008