Publications
Zudaire E, Gambardella L, Kurcz C, Vermeren S (2011) A computational tool for quantitative analysis of vascular networks.
PLoS ONE 6 e27385
http://dx.doi.org/10.1371/journal.pone.0027385
To download the free software and to access the helpmenu, visit http://angiotool.nci.nih.gov
Gambardella L, Anderson KE, Nussbaum C, Segonds-Pichon A, Margarido T, Norton L, Ludwig T, Sperandio M, Hawkins PT, Stephens LR, Vermeren S (In press) The GTPase-activating protein ARAP3 regulates chemotaxis and adhesion-dependent processes in neutrophils.
Blood 118: 1087-98
http://dx.doi.org/10.1182/blood-2010-10-312959
Gambardella L, Hemberger MC, Hughes B, Zudaire E, Andrews SR, Vermeren S (2010)
PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis.
Science Signaling 3 ra76
http://dx.doi.org/10.1126/scisignal.2001026
Authorised links from Science Signaling
Summary Abstract Reprint Full Text
Craig H.E., Guillou H., Coadwell J. and Vermeren S. (2010). ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences.
Cellular Signalling 22, 257-64.
http://dx.doi.org/10.1016/j.cellsig.2009.09.025
Craig H, Vermeren S (2007) Differential regulation of PI3Kγ in vivo by Ras and Gβγ.
Cellscience Reviews 3 1-5
www.cellscience.com/reviews11/Differential_regulation_PI3K.html (Online only)
Raaijmakers JH, Deneubourg L, Rehmann H, de Koning J, Zhang Z, Krugmann S, Erneux C, Bos JL (2007) The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
Cellular Signalling 19 1249-1257
http://dx.doi.org/10.1016/j.cellsig.2006.12.015
Krugmann S, Andrews SR, Stephens LR, Hawkins PT (2006) ARAP3 is essential for formulation of lamellipodia after growth factor stimulation.
Journal of Cell Science 119 425-432
http://dx.doi.org/10.1242/jcs.02755
Krugmann S, Williams R, Stephens LR, Hawkins PT (2004) ARAP3 is a PI3K- and Rap-regulated GAP for RhoA.
Current Biology 14 1380-1384
http://dx.doi.org/10.1016/j.cub.2004.07.058
Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor AH, Coadwell WJ, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis NT, Painter G, Thuring JW, Cooper MA, Lim Z-Y, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (2002) Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Molecular Cell 9 95-108
http://dx.doi.org/10.1016/S1097-2765(02)00434-3
Krugmann S, Jordens I, Gevaert K, Driessens M, Vandekerckhove J, Hall A (2001) Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex
Current Biology 11 1645-1655
http://dx.doi.org/10.1016/S0960-9822(01)00506-1
Updated 28 November, 2011