Selected Publications
Osborne CS, Ewels PA, Young ANC (2011) Meet the neighbours: tools to dissect nuclear structure and function.
Briefings in Functional Genomics 10 11-17
http://dx.doi.org/10.1093/bfgp/elq034
Krueger F, Andrews SR, Osborne CS (2011) Large scale loss of data in low-diversity Illumina sequencing libraries can be recovered by deferred cluster calling.
PLoS ONE 6 e16607
http://dx.doi.org/10.1371/journal.pone.0016607
Osborne CS, Eskiw CH (2008) Where shall we meet? A role for genome organisation and nuclear sub-compartments in mediating interchromosomal interactions.
Journal of Cellular Biochemistry 104 1553-1561
http://dx.doi.org/10.1002/jcb.21750
Miles J, Mitchell JA, Chakalova L, Goyenechea B, Osborne CS, O'Neill L, Tanimoto K, Engel JD, Fraser P (2007) Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.
PLoS ONE 2 e630
http://dx.doi.org/10.1371/journal.pone.0000630
Osborne CS, Chakalova L, Mitchell JA, Horton AM, Wood AL, Bolland DJ, Corcoran AE, Fraser P (2007) Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.
PLoS Biology 5 e192
http://dx.doi.org/10.1371/journal.pbio.0050192
Krueger C, Osborne CS (2006) Raising the curtains on interchromosomal interactions.
Trends in Genetics 22 637-639
http://dx.doi.org/10.1016/j.tig.2006.09.008
Chakalova L, Carter D, Debrand E, Goyenechea B, Horton A, Miles J, Osborne CS, Fraser P (2005) Developmental regulation of the β-globin gene locus.
Progress in Molecular and Subcellular Biology 38 183-206
http://dx.doi.org/10.1007/3-540-27310-7_8
Parker MJD, Licence ST, Erlandsson L, Galler GR, Chakalova L, Osborne CS, Morgan G, Fraser P, Jumaa H, Winkler TH, Skok J, Martensson I-L (2005) The pre-B-cell receptor induces silencing of VpreB and λ5 transcription.
EMBO Journal 24 3895-3905
http://dx.doi.org/10.1038/sj.emboj.7600850
Chakalova L, Debrand E, Mitchell JA, Osborne CS, Fraser P (2005) Replication and transcription: shaping the landscape of the genome.
Nature Reviews Genetics 6 669-677
http://dx.doi.org/10.1038/nrg1673
Rooks H, Bergounioux J, Game L, Close JP, Osborne CS, Best S, Senior T, Height S, Thompson R, Hadzic N, Fraser P, Bolton-Maggs P, Thein SL (2005) Heterogeneity of the εγδβ-thalassaemias: characterization of three novel English deletions.
British Journal of Haematology 128 722-729
http://dx.doi.org/10.1111/j.1365-2141.2005.05368.x
Chakalova L, Osborne CS, Dai Y-F, Goyenechea B, Metaxotou-Mavromati A, Kattamis A, Kattamis C, Fraser P (2005) The Corfu δβ thalassemia deletion disrupts γ-globin gene silencing and reveals post-transcriptional regulation of HbF expression.
Blood 105 2154-2160
http://dx.doi.org/10.1182/blood-2003-11-4069
Wu J, Iwata F, Grass JA, Osborne CS, Elnitski L, Fraser P, Ohneda O, Yamamoto M, Bresnick EH (2005) Molecular determinants of NOTCH4 transcription in vascular endothelium.
Molecular and Cellular Biology 25 1458-1474
http://dx.doi.org/10.1128/MCB.25.4.1458-1474.2005
Osborne CS, Chakalova L, Brown KE, Carter D, Horton A, Debrand E, Goyenechea B, Mitchell JA, Lopes S, Reik W, Fraser P (2004) Active genes dynamically co-localize to shared sites of ongoing transcription.
Nature Genetics 36 1065-1071
http://dx.doi.org/10.1038/ng1423
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, De Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Science 302 415-419
http://dx.doi.org/10.1126/science.1088547
Harteveld CL, Osborne CS, Peters M, Van der Werf S, Plug R, Fraser P, Giordano PC (2003) Novel 112 kb (εGγAγ) δβ-thalassaemia deletion in a Dutch family.
British Journal of Haematology 122 855-858
http://dx.doi.org/10.1046/j.1365-2141.2003.04505.x
Yao S, Osborne CS, Bharadwaj RR, Pasceri P, Sukonnik T, Pannell D, Recillas-Targa F, West AG, Ellis J (2003) Retrovirus silencer blocking by the cHS4 insulator is CTCF independent.
Nucleic Acids Research 31 5317-5323
http://dx.doi.org/10.1093/nar/gkg742
Carter D, Chakalova L, Osborne CS, Dai Y-F, Fraser P (2002) Long-range chromatin regulatory interactions in vivo.
Nature Genetics 32 623-626
http://dx.doi.org/10.1038/ng1051
Updated 23 August, 2011