Key Publications
Ramadani F, Bolland D, Garcon F, Emery JL, Vanhaesebroeck B, Corcoran AE, Okkenhaug K (2010)
The PI3K isoforms p110α and p110δ are essential for pre-B cell receptor signaling and B cell development.
Science Signaling 3 ra60
Summary |
Abstract |
Reprint |
Full text
Soond DR, Bjorgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JSH, Tasken K, Bunyard P, Okkenhaug K (2010)
PI3K p110δ regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.
Blood 115 2203-2213
http://dx.doi.org/10.1182/blood-2009-07-232330
Selman C, Tullet JMA, Wieser D, Irvine E, Lingard SJ, Choudhury AI, Claret M, Al-Qassab H, Carmignac D, Ramadani F, Woods A, Robinson ICA, Schuster E, Batterham RL, Kozma SC, Thomas G, Carling D, Okkenhaug K, Thornton JM, Partridge L, Gems D, Withers DJ (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.
Science 326 140-144
http://dx.doi.org/10.1126/science.1177221
Salmond RJ, Emery J, Okkenhaug K, Zamoyska R (2009) MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells.
Journal of Immunology 183 7388-7397
http://dx.doi.org/10.4049/jimmunol.0902294
Kohlhaas S, Garden OA, Scudamore C, Turner M, Okkenhaug K, Vigorito E (2009) The Foxp3 target miR-155 contributes to the development of regulatory T cells.
Journal of Immunology 182 2578-2582
http://dx.doi.org/10.4049/jimmunol.0803162
Saudemont A, Garcon F, Yadi H, Roche-Molina M, Kim N, Segonds-Pichon A, Martin-Fontecha A, Okkenhaug K, Colucci F (2009) p110γ and p110δ isoforms of phosphoinositide 3-kinase differentially regulate natural killer cell migration in health and disease.
Proceedings of the National Academy of Sciences of the United States of America 106 5795-5800
http://dx.doi.org/10.1073/pnas.0808594106
Gogishvili T, Elias F, Emery JL, McPherson K, Okkenhaug K, Hunig T, Dennehy KM (2008) Proliferative signals mediated by CD28 superagonists require the exchange factor Vav1 but not the phosphoinositide 3-kinase in primary peripheral T cells. European Journal of Immunology 38 2528-2533
http://dx.doi.org/10.1002/eji.200838223
Guillermet-Guibert J, Bjorklof K, Salpekar A, Gonella C, Ramadani F, Bilancio A, Meek S, Smith AJH, Okkenhaug K, Vanhaesebroeck B (2008) The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ.
Proceedings of the National Academy of Sciences of the United States of America 105 8292-8297
http://dx.doi.org/10.1073/pnas.0707761105
Selman C, Lingard S, Choudhury AI, Batterham RL, Claret M, Clements M, Ramadani F, Okkenhaug K, Schuster E, Blanc E, Piper MD, Al-Qassab H, Speakman JR, Carmignac D, Robinson ICA, Thornton JM, Gems D, Partridge L, Withers DJ (2008) Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice.
FASEB Journal 22 807-818
http://dx.doi.org/10.1096/fj.07-9261com
Jarmin SJ, David R, Ma L, Chai J-G, Dewchand H, Takesono A, Ridley AJ, Okkenhaug K, Marelli-Berg FM (2008) T cell receptor-induced phosphoinositide-3-kinase p110δ activity is required for T cell localization to antigenic tissue in mice.
Journal of Clinical Investigation 118 1154-1164
http://dx.doi.org/10.1172/JCI33267
Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, Okkenhaug K, Hagenbeek TJ, Spits H, Cantrell DA (2008) Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking.
Nature Immunology 9 513-521
http://dx.doi.org/10.1038/ni.1603
Garcon F, Patton DT, Emery JL, Hirsch E, Rottapel R, Sasaki T, Okkenhaug K (2008) CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.
Blood 111 1464-1471
http://dx.doi.org/10.1182/blood-2007-08-108050
Ji H, Rintelen F, Waltzinger C, Meier DB, Bilancio A, Pearce W, Hirsch E, Wymman MP, Ruckle T, Camps M, Vanhaesebroeck B, Okkenhaug K, Rommel C (2007) Inactivation of PI3Kγ and PI3Kδ distorts T-cell development and causes multiple organ inflammation.
Blood 110 2940-2947
http://dx.doi.org/10.1182/blood-2007-04-086751
Marelli-Berg FM, Okkenhaug K, Mirenda V (2007) A two-signal model for T cell trafficking.
Trends in Immunology 28 267-273
http://dx.doi.org/10.1016/j.it.2007.04.008
Mirenda V, Jarmin SJ, David R, Dyson J, Scott D, Gu Y, Lechler RI, Okkenhaug K, Marelli-Berg FM (2007) Physiologic and aberrant regulation of memory T cell trafficking by the costimulatory molecular CD28.
Blood 109 2968-2977
http://dx.doi.org/10.1182/blood-2006-10-050724
Okkenhaug K, Ali K, Vanhaesebroeck B (2007) Antigen receptor signalling: a distinctive role for the p110δ isoform of PI3K.
Trends in Immunology 28 80/87
http://dx.doi.org/10.1016/j.it.2006.12.007
Patton DT, Garcon F, Okkenhaug K (2007) The PI3K p110δ controls T cell development, differentiation and regulation.
Biochemical Society Transactions 35 167-171
http://www.biochemsoctrans.org/bst/ev/035/0167/bst0350167_ev.htm
Rodriguez A, Vigorito E, Clare S, Warren MV, Couttet P, Soond DA, Van Dongen S, Grocock RJ, Das PP, Miska EA, Vetrie D, Okkenhaug K, Enright AJ, Dougan G, Turner M, Bradley A (2007) Requirement of bic/microRNA-155 for normal immune function.
Science 316 608-611
http://dx.doi.org/10.1126/science.1139253
Bilancio A, Okkenhaug K, Camps M, Emery JL, Ruckle T, Rommel C, Vanhaesebroeck B (2006) Key role of the p110δ isoform of PI3K in B cell antigen and IL4 receptor signalling: comparative analysis of genetic and pharmacological interference with p110δ function in B cells.
Blood 107 642-650
http://dx.doi.org/10.1182/blood-2005-07-3041
Okkenhaug K, Patton DT, Bilancio A, Garcon F, Rowan WC, Vanhaesebroeck B (2006) The p110δ isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th Cells.
Journal of Immunology 177 5122-5128
http://www.jimmunol.org/cgi/content/abstract/177/8/5122
Patton DT, Garden OA, Pearce WP, Clough LE, Monk CR, Leung E, Rowan WC, Sancho S, Walker LSK, Vanhaesebroeck B, Okkenhaug K (2006) The phosphoinositide 3-kinase p110δ is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.
Journal of Immunology 177 6598-6602
http://www.jimmunol.org/cgi/content/abstract/177/10/6598
Okkenhaug K, Vanhaesebroeck B (2003) PI3K in lymphocyte development, differentiation and activation.
Nature Reviews Immunology 3 317-330
http://dx.doi.org/10.1038/nri1056