Recent selected publications
Hawkins PT, Stephens LR (2007) PI3Kγ is a key regulator of inflammatory responses and cardiovascular homeostasis.
Science 318 64-66
DOI link: http://dx.doi.org/10.1126/science.1145420
Abstract: Click here
Full text: Click here
Ferguson GJ, Milne L, Kulkarni S, Sasaki T, Walker S, Andrews S, Crabbe T, Finan P, Jones G, Jackson S, Camps M, Rommel C, Wymann M, Hirsch E, Hawkins PT, Stephens LR (2007) PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis.
Nature Cell Biology 9 86-91
http://dx.doi.org/10.1038/ncb1517
Ellson CD, Davidson K, Ferguson GJ, O'Connor R, Stephens LR, Hawkins PT (2006) Neutrophils from p40phox-/- mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing.
Journal of Experimental Medicine 203 1927-1937
http://dx.doi.org/10.1084/jem.20052069
Suire S, Condliffe AM, Ferguson GJ, Ellson CD, Guillou H, Davidson K, Welch HCE, Coadwell WJ, Turner M, Chilvers ER, Hawkins PT, Stephens LR (2006) Gβγs and the Ras binding domain of p110γ are both important regulators of PI(3)Kγ signalling in neutrophils.
Nature Cell Biology 8 1303-1309
http://dx.doi.org/10.1038/ncb1494
Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, Vanhaesebroeck B, Turner M, Webb LMC, Wymann MP, Hirsch E, Ruckle T, Camps M, Rommel C, Jackson SP, Chilvers ER, Stephens LR, Hawkins PT (2005) Sequential activation of Class IB and Class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils.
Blood 106 1432-1440
http://dx.doi.org/10.1182/blood-2005-03-0944
Suire S, Coadwell WJ, Ferguson GJ, Davidson K, Hawkins PT, Stephens LR (2005) p84, a new Gβγ-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110γ.
Current Biology 15 566-570
http://dx.doi.org/10.1016/j.cub.2005.02.020
Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor AH, Coadwell WJ, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis NT, Painter G, Thuring JW, Cooper MA, Lim Z-Y, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (2002) Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Molecular Cell 9 95-108
http://dx.doi.org/10.1016/S1097-2765(02)00434-3
Welch HCE, Coadwell WJ, Ellson CD, Ferguson GJ, Andrews SR, Erdjument-Bromage H, Tempst P, Hawkins PT, Stephens LR (2002) P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-regulated guanine-nucleotide exchange factor for Rac.
Cell 108 809-821
http://dx.doi.org/10.1016/S0092-8674(02)00663-3
Ellson CD, Anderson KE, Morgan G, Chilvers ER, Lipp P, Stephens LR, Hawkins PT (2001) Phosphatidylinositol 3-phosphate is generated in phagosomal membranes.
Current Biology 11 1631-1635
http://dx.doi.org/10.1016/S0960-9822(01)00447-X
Ellson CD, Gobert-Gosse S, Anderson KE, Davidson K, Erdjument-Bromage H, Tempst P, Thuring JW, Cooper MA, Lim Z-Y, Holmes AB, Gaffney PRJ, Coadwell WJ, Chilvers ER, Hawkins PT, Stephens LR (2001) PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox.
Nature Cell Biology 3 679-682
http://dx.doi.org/10.1038/35083076
Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens LR, Eccleston JF, Williams RL (2000) Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase γ.
Cell 103 931-943
http://dx.doi.org/10.1016/S0092-8674(00)00196-3
Updated 24 August, 2011