Recent selected publications
Eskiw C, Fraser P (In press) Ultra-structural study of transcription factories in mouse erythroblasts.
Journal of Cell Science
Nagano T, Fraser P (2011) No-nonsense functions for long noncoding RNAs.
Cell 145 178-181
http://dx.doi.org/10.1016/j.cell.2011.03.014
Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews SR, Kurukuti S, Mitchell JA, Umlauf D, Dimitrova DS, Eskiw CH, Luo Y, Wei C-L, Ruan Y, Bieker JJ, Fraser P (2010) Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.
Nature Genetics 42 53-61
http://dx.doi.org/10.1038/ng.496
Hadjur S, Williams LM, Ryan NK, Cobb BS, Sexton T, Fraser P, Fisher AG, Merkenschlager M (2009) Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus.
Nature 460 410-413
http://dx.doi.org/10.1038/nature08079
Nagano T, Mitchell JA, Sanz LA, Pauler FM, Ferguson-Smith AC, Feil R, Fraser P (2008) The Air noncoding RNA epigenetically silences transcription by targeting G9a to chromatin.
Science 322 1717-1720
http://dx.doi.org/10.1126/science.1163802
Mitchell JA, Fraser P (2008) Transcription factories are nuclear subcompartments that remain in the absence of transcription.
Genes and Development 22 20-25
http://dx.doi.org/10.1101/gad.454008
Fraser P, Bickmore W (2007) Nuclear organization of the genome and the potential for gene regulation.
Nature 447 413-417
http://dx.doi.org/10.1038/nature05916
Osborne CS, Chakalova L, Mitchell JA, Horton AM, Wood AL, Bolland DJ, Corcoran AE, Fraser P (2007) Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.
PLoS Biology 5 e192
http://dx.doi.org/10.1371/journal.pbio.0050192
Chakalova L, Debrand E, Mitchell JA, Osborne CS, Fraser P (2005) Replication and transcription: shaping the landscape of the genome.
Nature Reviews Genetics 6 669-677
http://dx.doi.org/10.1038/nrg1673
Bolland DJ, Wood AL, Johnston CM, Bunting SF, Morgan G, Chakalova L, Fraser P, Corcoran AE (2004) Antisense intergenic transcription in V(D)J recombination.
Nature Immunology 5 630-637
http://dx.doi.org/10.1038/ni1068
Osborne CS, Chakalova L, Brown KE, Carter D, Horton A, Debrand E, Goyenechea B, Mitchell JA, Lopes S, Reik W, Fraser P (2004) Active genes dynamically co-localize to shared sites of ongoing transcription.
Nature Genetics 36 1065-1071
http://dx.doi.org/10.1038/ng1423
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, De Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.
Science 302 415-419
http://dx.doi.org/10.1126/science.1088547
Carter D, Chakalova L, Osborne CS, Dai Y-F, Fraser P (2002) Long-range chromatin regulatory interactions in vivo.
Nature Genetics 32 623-626
http://dx.doi.org/10.1038/ng1051
Gribnau J, Diderich K, Pruzina S, Calzolari R, Fraser P (2000) Intergenic transcription and developmental remodeling of chromatin subdomains in the human β-globin locus.
Molecular Cell 5 377-386
http://dx.doi.org/10.1016/S1097-2765(00)80432-3
Updated 20 January, 2012