Selected publications
Gilley J, Seereeram A, Ando K, Mosely S, Andrews SR, Kerschensteiner M, Misgeld T, Brion J-P, Anderton B, Hanger DP, Coleman MP (In press) Age-dependent axonal transport and locomotor changes and tau hypophosphorylation in a "P301L" tau knockin mouse.
Neurobiology of Aging
http://dx.doi.org/10.1016/j.neurobiolaging.2011.02.014
Meyer zu Horste G, Miesbach TA, Muller JI, Fledrich R, Stassart RM, Kieseier BC, Coleman MP, Sereda MW (2011) The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degeneration.
Neurobiology of Disease 42 1-8
http://dx.doi.org/10.1016/j.nbd.2010.12.006
Gilley J, Adalbert R, Coleman MP (2011) Modelling early responses to neurodegenerative mutations in mice.
Biochemical Society Transactions 39 933-938
http://dx.doi.org/10.1042/BST0390933
Conforti L, Janeckova L, Wagner D, Mazzola F, Cialabrini L, Di Stefano M, Orsomando G, Magni G, Bendotti C, Smyth N, Coleman MP (2011) Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.
FEBS Journal 278 2666-2679
http://dx.doi.org/10.1111/j.1742-4658.2011.08193.x
Coleman MP (2011) Molecular signalling: how do axons die?
Advances in Genetics 73 185-217
http://dx.doi.org/10.1016/B978-0-12-380860-8.00005-7
Andrews SR, Gilley J, Coleman MP (2010) Difference Tracker: ImageJ plugins for fully automated analysis of multiple axonal transport parameters.
Journal of Neuroscience Methods 193 281-287
http://dx.doi.org/10.1016/j.jneumeth.2010.09.007
Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thompson D, Ribchester RR, Coleman MP (2010) Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.
Journal of Neuroscience 30 13291-13304
http://dx.doi.org/10.1523/JNEUROSCI.1189-10.2010
Coleman MP, Freeman MR (2010) Wallerian degeneration, WLDS and Nmnat.
Annual Review of Neuroscience 33 245-267
http://dx.doi.org/10.1146/annurev-neuro-060909-153248
Gilley J, Coleman MP (2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.
PLoS Biology 8 e1000300
http://dx.doi.org/10.1371/journal.pbio.1000300
Wong F, Fan L, Wells S, Hartley R, Mackenzie FE, Oyebode O, Brown R, Thomson D, Coleman MP, Blanco G, Ribchester RR (2009) Axonal and neuromuscular synaptic phenotypes in WldS, SOD1G93A and ostes mutant mice identified by fiber-optic confocal microendoscopy.
Molecular and Cellular Neuroscience 42 296-307
http://dx.doi.org/10.1016/j.mcn.2009.08.002
Conforti L, Wilbrey AL, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman MP (2009) WldS protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.
Journal of Cell Biology 184 491-500
http://dx.doi.org/10.1083/jcb.200807175
Morreale G, Conforti L, Coadwell WJ, Wilbrey AL, Coleman MP (2009) Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.
FEBS Journal 276 1208-1220
http://dx.doi.org/10.1111/j.1742-4658.2008.06858.x
Beirowski B, Babetto E, Gilley J, Mazzola F, Conforti L, Janeckova L, Magni G, Ribchester RR, Coleman MP (2009) Non-nuclear WldS determines its neuroprotective efficacy for axons and synapses in vivo.
Journal of Neuroscience 29 653-668
http://dx.doi.org/10.1523/JNEUROSCI.3814-08.2009
Adalbert R, Nogradi A, Babetto E, Janeckova L, Walker SA, Kerschensteiner M, Misgeld T, Coleman MP (2009) Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies.
Brain 132 402-416
http://dx.doi.org/10.1093/brain/awn312
Beirowski B, Babetto E, Coleman MP, Martin KR (2008) The WldS gene delays axonal but not somatic degeneration in a rat glaucoma model.
European Journal of Neuroscience 28 1166-1179
http://dx.doi.org/10.1111/j.1460-9568.2008.06426.x
Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R, Gillingwater TH, Smith T, Wyllie DJA, Ribchester RR, Coleman MP (2008) VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, WldS.
Molecular and Cellular Neuroscience 38 325-340
http://dx.doi.org/10.1016/j.mcn.2008.03.004
Bridge KE, Berg N, Adalbert R, Babetto E, Dias T, Spillantini M-G, Ribchester RR, Coleman MP (2009) Late onset distal axonal swelling in YFP-H transgenic mice.
Neurobiology of Aging 30 309-321
http://dx.doi.org/10.1016/j.neurobiolaging.2007.06.002
Adalbert R, Gilley J, Coleman MP (2007) Aβ, tau and ApoE4 in Alzheimer's disease: the axonal connection.
Trends in Molecular Medicine 13 135-142
http://dx.doi.org/10.1016/j.molmed.2007.02.004
Conforti L, Adalbert R, Coleman MP (2007) Neuronal death: where does the end begin?
Trends in Neurosciences 30 159-166
http://dx.doi.org/10.1016/j.tins.2007.02.004
Conforti L, Fang G, Beirowski B, Wang MS, Sorci L, Asress S, Adalbert R, Silva A, Bridge K, Huang XP, Magni G, Glass JD, Coleman MP (2007) NAD+ and axon degeneration revisited: Nmnat1 cannot substitute for WldS to delay Wallerian degeneration.
Cell Death and Differentiation 14 116-127
http://dx.doi.org/10.1038/sj.cdd.4401944
Adalbert R, Nogradi A, Szabo A, Coleman MP (2006) The slow Wallerian degeneration gene in vivo protects motor axons but not their cell bodies after avulsion and neonatal axotomy.
European Journal of Neuroscience 24 2163-2168
http://dx.doi.org/10.1111/j.1460-9568.2006.05103.x
Laser H, Conforti L, Morreale G, Mack TGM, Heyer M, Haley JE, Wishart TM, Beirowski B, Walker SA, Haase G, Celik A, Adalbert R, Wagner D, Grumme D, Ribchester RR, Plomann M, Coleman MP (2006) The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.
Molecular Biology of the Cell 17 1075-1084
http://dx.doi.org/10.1091/mbc.E05-04-0375
Coleman MP (2005) Axon degeneration mechanisms: commonality amid diversity.
Nature Reviews Neuroscience 6 889-898
http://dx.doi.org/10.1038/nrn1788
Adalbert R, Gillingwater TH, Haley JE, Bridge K, Beirowski B, Berek L, Wagner D, Grumme D, Thomson D, Celik A, Addicks K, Ribchester RR, Coleman MP (2005) A rat model of slow Wallerian degeneration (WldS) with improved preservation of neuromuscular synapses.
European Journal of Neuroscience 21 271-277
http://dx.doi.org/10.1111/j.1460-9568.2004.03833.x
Mi W, Beirowski B, Gillingwater TH, Adalbert R, Wagner D, Grumme D, Osaka H, Conforti L, Arnhold S, Addicks K, Wada K, Ribchester RR, Coleman MP (2005) The slow Wallerian degeneration gene, WldS, inhibits axonal spheroid pathology in gracile axonal dystrophy mice.
Brain 128 405-416
http://dx.doi.org/10.1093/brain/awh368
Mack TGA, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater TH, Court F, Conforti L, Fernando FS, Tarlton A, Andressen C, Addicks K, Magni G, Ribchester RR, Perry VH, Coleman MP (2001) Wallerian degeneration of injured axons and synapses is delayed by a Ube4B/Nmnat chimeric gene.
Nature Neuroscience 4 1199-1206
http://dx.doi.org/10.1038/nn770
Updated 5 September, 2011