Life Sciences Research for Lifelong Health

Karen Lipkow

​Research in our lab focuses on the three-dimensional organisation of the eukaryotic genome. We are taking an integrated approach to analyse its structure, individual variability and dynamics. Our analysis is aimed at revealing common rules linking changes in genome organisation to the regulation of gene expression.

Nucleus modelWe are investigating various aspects of genome architecture using detailed computational models of the nucleus, quantitative fluorescent live cell microscopy, chromatin conformation capture (3C, Hi-C), functional genomics and proteomics.

The questions we are addressing are how does genome structure change over time and in response to external conditions, which are the molecular and biophysical mechanisms responsible for these changes, and which are the biological consequences. We maintain an interest in spatial aspects of signalling in the bacterial chemotaxis system.

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Latest Publications

Systems Biology Approaches for Understanding Genome Architecture.

Sewitz S, Lipkow K

Methods in molecular biology (Clifton, N.J.)
1431 1940-6029:109-26 (2016)

PMID: 27283305

The autoregulation of a eukaryotic DNA transposon.

C Claeys Bouuaert, K Lipkow, SS Andrews

eLife
2 :e00668 (2013)

DOI: 10.7554/eLife.00668

PMID: 23795293

Model for Protein Concentration Gradients in the Cytoplasm.

K Lipkow, DJ Odde

Cellular and molecular bioengineering
1 1:84-92 (2008)

DOI: 10.1007/s12195-008-0008-8

PMID: 21152415

Introducing simulated cellular architecture to the quantitative analysis of fluorescent microscopy.

MA DePristo, L Chang, RD Vale

Progress in biophysics and molecular biology
100 1-3:25-32 (2009)

DOI: 10.1016/j.pbiomolbio.2009.07.002

PMID: 19628003

Amelioration of protein misfolding disease by rapamycin: translation or autophagy?

A Wyttenbach, S Hands, MA King

Autophagy
4 4:542-5 (2008)

PMID: 18418060

The chemotactic behavior of computer-based surrogate bacteria.

D Bray, MD Levin, K Lipkow

Current biology : CB
17 1:12-9 (2007)

DOI: 10.1016/j.cub.2006.11.027

PMID: 17208180

Rapid turnover of stereocilia membrane proteins: evidence from the trafficking and mobility of plasma membrane Ca(2+)-ATPase 2.

M Grati, ME Schneider, K Lipkow

The Journal of neuroscience : the official journal of the Society for Neuroscience
26 23:6386-95 (2006)

DOI: 10.1523/JNEUROSCI.1215-06.2006

PMID: 16763047

Changing cellular location of CheZ predicted by molecular simulations.

Lipkow K

PLoS computational biology
2 1553-7358:e39 (2006)

PMID: 16683020

Simulated diffusion of phosphorylated CheY through the cytoplasm of Escherichia coli.

K Lipkow, SS Andrews, D Bray

Journal of bacteriology
187 1:45-53 (2005)

DOI: 10.1128/JB.187.1.45-53.2005

PMID: 15601687