Life Sciences Research for Lifelong Health

Marc Veldhoen

Epithelial barrier sites such as the skin, respiratory and gastrointestinal tract, form a physical interface between our bodies and external environments. In addition to creating a physical impediment to pathogens, epithelial barriers include a diverse mix of immune cells, forming a first line of defence against invading pathogens.

immune systemsOur laboratory studies the role that cells of the immune system play at the initiation, modulation and resolution of immune responses at epithelial barrier sites. These studies provide insights into the mechanisms that control the maintenance of a resident population of micro-organisms, promoting healthy living, and the prevention of undesirable immune responses that may result in chronic infections, allergies, autoimmunity and an increased risk of cancer.

A specialised subset of white blood cells, the intra-epithelial lymphocytes (IELs), reside just beneath the epithelial barrier of skin and intestine. They are positioned to be the first members of the immune system to interact with, and respond to, microbial populations. In addition, they help maintain a physical barrier. Our group had demonstrated that the AhR, a receptor molecule expressed in IELs, is a crucial component for the maintenance of the IEL populations in skin and gut. This demonstrates the important roles AhR play in maintaining the physical and immunological barriers that contribute to our lifelong health and well-being..

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Latest Publications

Cellular Plasticity of CD4+ T Cells in the Intestine.

V Brucklacher-Waldert, EJ Carr, MA Linterman

Frontiers in immunology
5 1664-3224:488 (2014)

PMID: 25339956

Persistence of skin-resident memory T cells within an epidermal niche.

A Zaid, LK Mackay, A Rahimpour

Proceedings of the National Academy of Sciences of the United States of America
111 14:5307-12 (2014)

DOI: 10.1073/pnas.1322292111

PMID: 24706879

Regulation of Experimental Autoimmune Encephalomyelitis by TPL-2 Kinase.

S Sriskantharajah, E Gückel, N Tsakiri

Journal of immunology (Baltimore, Md. : 1950)
192 8:3518-29 (2014)

DOI: 10.4049/jimmunol.1300172

PMID: 24639351

The aryl hydrocarbon receptor in innate T cell immunity.

J Stange, M Veldhoen

Seminars in immunopathology
: (2013)

DOI: 10.1007/s00281-013-0389-1

PMID: 24030775

Dietary influences on intestinal immunity.

M Veldhoen, V Brucklacher-Waldert

Nature reviews. Immunology
12 10:696-708 (2012)

DOI: 10.1038/nri3299

PMID: 23007570

Host and microbes date exclusively.

C Ferreira, M Veldhoen

Cell
149 7:1428-30 (2012)

DOI: 10.1016/j.cell.2012.06.005

PMID: 22726431

IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection.

B Mastelic, AP do Rosario, M Veldhoen

Frontiers in immunology
3 :85 (2012)

DOI: 10.3389/fimmu.2012.00085

PMID: 22566965

Direct interactions between intestinal immune cells and the diet.

M Veldhoen

Cell cycle (Georgetown, Tex.)
11 3:426-7 (2012)

DOI: 10.4161/cc.11.3.19163

PMID: 22262170

T helper cell differentiation more than just cytokines.

B Zygmunt, M Veldhoen

Advances in immunology
109 :159-96 (2011)

DOI: 10.1016/B978-0-12-387664-5.00005-4

PMID: 21569915