The Epigenetics ISP

The Epigenetics ISP seeks to understand how epigenetic changes regulate genome function, especially during development and in response to external signals. We aim to identify adaptations important for healthy ageing and wellbeing, including transgenerational effects. The Babraham Institute is amongst the world’s 10 leading research centres in epigenetics research: www.sciencewatch.com/inter/ins/09/09marEpigentop20.

Developmental decisions in all organisms are accompanied by epigenetic modifications of DNA or chromatin, and by genome regulation through non-coding RNAs and higher order chromatin structures. We are studying the mechanisms involved in establishing, maintaining and reprogramming epigenetic modifications in the genome during key stages in germ cells, embryos and lineage specification.

We develop and exploit relevant model organisms, locus-specific and genome-wide approaches, as well as  increasingly sophisticated computational methods and modelling approaches. We are addressing how signalling events can regulate and modify epigenetic marks in stem cells and in early embryos, where these mechanisms control lineage commitment to the embryonic and extraembryonic (placenta) lineages. We are determining epigenomes and coding and noncoding RNA profiles, particularly in germ cells, early embryos, stem cells (including ES, TS, XEN, and EpiSC cells) and in some particularly relevant physiological models.

For this we use High Throughput Sequencing technologies and have adapted these to work for small cell numbers, as well as developing novel epigenomics computational methods. We are also interested in mechanisms that remove key epigenetic marks, allowing epigenetic reprogramming and providing crucial insights into transgenerational effects in mammalian health and ageing, as well as novel approaches to regenerative medicine.

Our research is making vital contributions to revealing the biological mechanisms underlying normal physiology and homeostatic control during early development and through life. Our work is supported by BBSRC, MRC, The Wellcome Trust, the European Union, and Industry.

Key publications from the Epigenetics ISP

Translating the ISP's Research into Action (KEC)

Public Engagement

Skills training

Other Links

The Epigenome
Harwell Imprinting site
SAVOIR
CellCentric
University of Melbourne