The Epigenetics ISP - Research into Action

Aims and potential for translation of our research

Research in the Epigenetics ISP focuses on understanding genetic and epigenetic mechanisms in mammalian development. Of particular interest are early development of the embryo and of the placenta, which has important roles in nourishment of the fetus. Placental malformation or malfunction underlies many complications during pregnancy and can compromise the health of the fetus and the future health of the growing and adult organism. We are studying imprinted genes, whose correct epigenetic regulation is of critical importance for fetal growth, placental function, and metabolic and physiological adaptations after birth (including for example thermogenesis and fat metabolism). Deregulation of imprinting causes human diseases ranging from fetal growth disorders to obesity to cancer. Finally, we study epigenetic reprogramming in germ cells and early embryos, and aim to isolate factors that might be used to increase the efficiency of reprogramming of adult cells to stem cells for applications in regenerative medicine.

Commercial Collaborations

4 research collaborations with industry
(Wolf Reik, Myriam Hemberger, Gavin Kelsey)

1 CASE studentship (Reik group)

2 active patent applications (Wolf Reik, Gavin Kelsey)

1 consultancy agreement (Wolf Reik)

An antibody against 5-hmC developed by the Reik group has been licensed to several companies, and also is available through the Institute’s Antibody Facility

Clinical and pre-clinical collaborations

Biomedicum Helsinki, University of Helsinki:
Imprinted genes in human pancreatic development. (Gavin Kelsey)

Dept of Anatomy, University of Cambridge and Institute of Reproductive & Developmental Biology, Imperial College London: Role of cathepsin proteases in the development of placental pathologies.
(Myriam Hemberger)

Dept of Medical & Molecular Genetics, University of Birmingham:
Genetic defects in imprinted gene syndromes. (Gavin Kelsey)

Division of Human Genetics, University of Southampton:
Genetic defects in imprinted gene syndromes. (Gavin Kelsey)

Institute of Cancer Research, University of London:
Genetic defects in imprinted gene syndromes. (Gavin Kelsey)

Leeds Institute of Genetics, Health & Therapeutics, University of Leeds:
Imprinted genes and human germ cell potential. (Gavin Kelsey)