The Babraham Institute receives strategic funding from the BBSRC
The Babraham Institute receives strategic funding from the BBSRC
Michael Coleman, Gavin Kelsey, Klaus Okkenhaug, Patrick Varga-Weisz
Ageing research is driven by the need to understand how we age and to increase healthy lifespan. However, the study of ageing also reveals novel molecular, genetic and cellular mechanisms important for wider understanding of basic biology. This meeting will highlight the most exciting recent advances in ageing research. It will discuss innovative techniques and the model organisms in which they are applied, and it will consider how understanding of basic bioscience contributes to, and benefits from research into ageing. Topics will include epigenetics, stem cells, ageing immune and nervous systems, senescence, insulin/IGF and TOR signalling.
PROGRAMME
Thursday 20th September
08.30 – 08.50
Registration and refreshments Barry Cross Conference Centre, Babraham Institute, Cambridge
08.50 – 09.00 Opening remarks
Session 1: Longevity Chair: Thomas Rando (Stanford University
09.00 – 09.30
Linda Partridge (Institute of Healthy Ageing, UCL and Max Planck Institute for Biology of Ageing, Cologne)
Nutrient sensing pathways and ageing
09.30 – 10.00
Paul Coffer (University Medical Centre, Utrecht)
Regulating lifespan through FOXO mediated modulation of metabolism and autophagy
10.00 – 10.30
Morning refreshment break
10.30 – 11.00
Richard Miller (University of Michigan, Ann Arbor)
Stress resistance in cells and tissues of slow-ageing mice
11.00 – 11.30
Age UK Speaker: Eric Greer (Harvard Medical School)
Transgenerational epigenetic inheritance of longevity in C. elegans.
11.30 – 11.45
Short selected talk: Michèle Riesen (Institute of Healthy Ageing, UCL)
Identification and characterization of DAF-16/FoxO targets that control lifespan in C. elegans
11.45 – 13.45
Lunch and refreshments
Session 2: Immune and nervous system ageing Chair: Martin Turner (Babraham Institute, Cambridge)
13.45 – 14.15
Doron Melamed (Technion – Israel Institute of Technology, Haifa)
Homeostatic regulation of B lineage cells in ageing
14.15 – 14.45
Anne Corcoran (Babraham Institute, Cambridge)
Nuclear organization in the ageing haematopoietic system
14.45 – 15.15
Afternoon refreshment break
15.15 – 15.45
Arne Akbar (Division of Infection and Immunity, UCL)
Human experimental models for the study of immune ageing
15.45 – 16.00
Short selected talk: Diana Jurk (Institute for Ageing and Health, Newcastle)
Persistent pro-inflammatory signalling accelerates ageing
16.00 – 16.30
Michael Coleman (Babraham Institute, Cambridge)
Age-related decline in axonal transport and its consequences for axon longevity
16.30 – 17.00
Tony Wyss-Coray (Stanford University School of Medicine)
Circulatory factors as modulators of brain ageing
17.00 – 18.30 Poster session and refreshments
Friday 21st September
Session 3: Age-related disease and senescence Chair: Joao Passos (Institute of Ageing and Health, Newcastle)
08.45 – 09.15
David Kipling (School of Medicine, Cardiff)
Expression of innate immune response markers after bypass of senescence in human cells
09.15 – 09.45
Jan van Deursen (Mayo Clinic, Minnesota)
Role of cellular senescence in (early) ageing and age-related disease
09.45 – 10.15
Shin-Ichiro Imai (Washington University, St. Louis)
Understanding the systemic hierarchy of ageing/longevity control in mammals: the roles of SIRT1 and NAMPT in the NAD world
10.15 – 10.45
Morning refreshment break
10.45 – 11.15
Ken Rhodes (Biogen Idec, Cambridge, MA)
Drug Discovery for Age-related Neurodegenerative Diseases: A Biotech Perspective
11.15 – 11.45
Carlos Lopez-Otin (University of Oviedo)
Nuclear lamina alterations and premature ageing: from mechanisms to therapies
11.45 – 12.00
Short selected talk: Paul Potter (MRC Harwell, Oxford)
The Harwell ageing mutant screen
12.00 – 14.00 Lunch and refreshments
Session 4: Stem cells and chromatin, sponsored by The Genetics Society Chair: Michael Wakelam (Babraham Institute, Cambridge)
14.00 – 14.30
Thomas Rando (Stanford University)
Epigenetic mechanisms of stem cell ageing and rejuvenation
14.30 – 15.00
Tom Misteli (NIH, Bethesda)
Nuclear architecture, ageing and cancer
15.00 – 15.30
Masashi Narita (Cancer Research UK CRI, Cambridge)
Spatial reorganization of the genome during the formation of senescence associated heterochromatic foci, SAHF
15.30 – 16.00
Wolf Reik (Babraham Institute, Cambridge)
Epigenetic reprogramming in mammalian development
16.00 – 16.30
Closing remarks and refreshments
This Conference has been approved as
a Career Progression Development event
by the Society of Biology
Babraham Institute - Babraham Research Campus - Cambridge - United Kingdom