Cameron Osborne

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Nuclear organization and genome integrity

Genome integrity is maintained in the face of DNA damage and mutation by a collection of repair factors that act to correct these lesions as they develop. Yet on occasion the errors are not faithfully repaired and can result in the formation of chromosomal translocations. Remarkably, certain gene pairs are commonly rearranged with each other.

Our research focuses on how functional organization of the genome contributes to the propensity toward specific translocations, the subsequent impact of these events on genome organization, and how such deleterious events are held in check. (More...)