Cameron Osborne
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Nuclear Organization and Cancer

Chromosomal translocation between genes is often a triggering event that leads to a cellular transformation towards cancer. Much is known about the different gene fusion combinations that are associated with a variety of cancer types. Yet what is less clear is exactly where, when and how the chromosomal translocation takes place. We are interested in the contributions that the organization of the genome within the nucleus makes to the susceptibility to specific cancers and specifically the role that transcription plays. A better understanding of the process of chromosomal translocation generation may lead to the development of novel cancer treatments.