Peter Fraser - Head of Laboratory
Tel. (01223) 496644

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Research summary

Chromatin re-organization, higher-order chromatin structures involved in regulating gene transcription and nuclear organization of the genome are the main areas of interest in our group. We are examining the role of intergenic transcription, which is thought to remodel chromatin during development so that it is more ‘open’ for gene expression. We have also developed a powerful technique (RNA TRAP) with which chromatin interactions can be analysed in vivo, and have demonstrated for the first time that remote control regions such as enhancers can interact physically with the transcribed genes by ‘looping out’ intervening DNA. And we are studying the 3D conformation of the genome, in particular how potentially active genes access sub-nuclear compartments known as transcription factories.