Peter Fraser

Tel. (01223) 496644
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Research summary

Dynamic changes in chromatin and nuclear structure can regulate patterns of cellular gene expression during differentiation and development, or in response to environmental signals. Our research looks at various levels of chromatin, chromosome and nuclear structure, from individual nucleosome modifications to the dynamic 3D structure of chromosomes and their inter-relationships in the nucleus and how they affect genome functions.

Long-range chromatin interactions

Preferential associations between co-regulated genes
at transcription factories

Intergenic transcription

Non-coding RNA and epigenetic silencing of gene expression