The Nuclear Dynamics ISP - Aims and potential for translation of our research

Research in the Nuclear Dynamics ISP focuses on understanding genome function and control mechanisms with the overall aim of a greater understanding of genome regulation underpinning human health and disease. We are studying epigenetic mechanisms involved in establishing and maintaining gene expression programmes during DNA replication, placental development and establishment of the immune system. We are using novel techniques to study nuclear organization of the genome to discover its role in the susceptibility and generation of cancers as well as coordination of physiological functions and gene expression programmes. We also have long-standing interests in understanding the links between genetic mutations and hereditary disease conditions and in increasing knowledge and understanding to design and improve gene therapy regimes.

Commercial collaborations

5 research collaborations (Peter Fraser, Anne Corcoran, Sarah Elderkin, Cameron Osborne, Patrick Varga Weisz)

2 consultancy agreements (Anne Corcoran)

Clinical and pre-clinical collaborations

Cambridge Institute for Medical Research, University of Cambridge:
Nuclear organization and cancer (Cameron Osborne)

Dept of Haematological Medicine, Guy's Kings' & St Thomas' School of Medicine, King's College London:
Genomic defects in thalassemia (Peter Fraser & Cameron Osborne)

Dept of Human & Clinical Genetics, Leiden University Medical Center:
Hemoglobinopathies and thalassaemia (Peter Fraser & Cameron Osborne)

Dept of Immunobiology, King's College London School of Medicine:
Chromatin remodelling mechanisms underlying human antibody formation (Anne Corcoran)

Dept of Pediatrics, Agia Sophia Children's Hospital, Athens University:
Thalassemia and hereditary persistence of fetal hemoglobin (Peter Fraser & Cameron Osborne)

Dept of Pharmacology, University of Wisconsin Medical School:
Notch signalling and angiogenesis (Peter Fraser & Cameron Osborne)

INSERM Unit 429, Paris:
Gene therapy and cancer (Peter Fraser & Cameron Osborne)